Summer temperatures can reach the high 80s and low 90s, while winter temperatures often drop below freezing. The city sees a moderate amount of precipitation throughout the year, with snowfall in the winter months. Hannibal's climate offers distinct seasonal changes, making it an appealing destination for those who enjoy experiencing all four seasons.

Major attractions in Hannibal include the Mark Twain Boyhood Home and Museum, which offers a glimpse into the life and works of the beloved author. Visitors can also take a ride on the Mark Twain Riverboat, explore the historic Main Street district, or visit the Rockcliffe Mansion, a stunning example of Victorian architecture. In terms of institutions and schools, Hannibal is home to several public and private schools, as well as Hannibal-LaGrange University, a Christian liberal arts institution offering a range of undergraduate and graduate programs. The city's educational offerings contribute to its vibrant community and provide opportunities for residents of all ages.